Can humans really understand the universe?

I know that it sounds very arrogant but I refuse to believe that we are in a universe that is fundamentally outside our realm of understanding. It just seems that every time a new solution is found it always shows the elegance or symmetry of the universe which just indicates to me that there should be some way to make sense of it all. That being said I don't think that we are very close right now but we are making progress and maybe by the end of this century we will have most of it figured out. Just think that 100 years ago we knew nothing of quantum mechanics and used an abacus instead of a computer, imagine how quaint we'll look in another hundred years.